Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of <i>N</i>-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth.

Guo, Weikai; Xing, Yajing; Zhang, Qiansen; Xie, Jiuqing; Huang, Dongxia; Gu, Haijun; He, Peng; Zhou, Miaoran; Xu, Shifen; Pang, Xiufeng; Liu, Mingyao; Yi, Zhengfang; Chen, Yihua

Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth.

Guo, Weikai; Xing, Yajing; Zhang, Qiansen; Xie, Jiuqing; Huang, Dongxia; Gu, Haijun; He, Peng; Zhou, Miaoran; Xu, Shifen; Pang, Xiufeng; Liu, Mingyao; Yi, Zhengfang; Chen, Yihua.

Afiliação

Guo W; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Xing Y; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Zhang Q; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Xie J; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Huang D; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Gu H; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
He P; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Zhou M; Shanghai University of Traditional Chinese Medicine , Shanghai 200030 , China.
Xu S; Shanghai University of Traditional Chinese Medicine , Shanghai 200030 , China.
Pang X; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Liu M; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Yi Z; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.
Chen Y; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences , East China Normal University , 200241 Shanghai , China.

J Med Chem ; 63(2): 676-695, 2020 01 23.

Article em En | MEDLINE | ID: mdl-31895575

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Linfoma Difuso de Grandes Células B/tratamento farmacológico; Proteínas Proto-Oncogênicas c-bcl-6/antagonistas & inibidores; Pirimidinas/síntese química; Pirimidinas/farmacologia; Animais; Apoptose/efeitos dos fármacos; Proliferação de Células; Relação Dose-Resposta a Droga; Repressão Epigenética/efeitos dos fármacos; Centro Germinativo/efeitos dos fármacos; Células HEK293; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Modelos Moleculares; Simulação de Acoplamento Molecular; Proteínas Proto-Oncogênicas c-bcl-6/genética; Relação Estrutura-Atividade; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Pirimidinas / Linfoma Difuso de Grandes Células B / Proteínas Proto-Oncogênicas c-bcl-6 / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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