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Comparative analysis of the expression of metalloproteases (MMP-2, MMP-9, MMP-11 and MMP-13) and the tissue inhibitor of metalloprotease 3 (TIMP-3) between previous negative biopsies and radical prostatectomies. / Análisis comparativo de la expresión de metaloproteasas (MMP-2, MMP-9, MMP-11 y MMP-13) y del inhibidor tisular de la metaloproteasa 3 (TIMP-3) entre las biopsias previas negativas y las prostatectomías radicales.
Medina-González, A; Eiró-Díaz, N; Fernández-Gómez, J M; Ovidio-González, L; Jalón-Monzón, A; Casas-Nebra, J; Escaf-Barmadah, S.
Afiliação
  • Medina-González A; Servicio de Urología, Hospital Universitario Virgen de Valme, Sevilla, España. Electronic address: amedina1981@msn.com.
  • Eiró-Díaz N; Unidad de Investigación, Hospital Fundación de Jove, Gijón, España.
  • Fernández-Gómez JM; Servicio de Urología, Hospital Universitario Central de Asturias, Oviedo, España.
  • Ovidio-González L; Unidad de Investigación, Hospital Fundación de Jove, Gijón, España.
  • Jalón-Monzón A; Servicio de Urología, Hospital Universitario Central de Asturias, Oviedo, España.
  • Casas-Nebra J; Servicio de Urología, Hospital Lucus Augusti, Lugo, España.
  • Escaf-Barmadah S; Servicio de Urología, Hospital Universitario Central de Asturias, Oviedo, España.
Actas Urol Esp (Engl Ed) ; 44(2): 78-85, 2020 Mar.
Article em En, Es | MEDLINE | ID: mdl-31899007
ABSTRACT
Metalloproteases (MMPs) and tissue inhibitor of metalloprotease-3 (TIMP-3) have been associated to the risk of having cancer and tumor aggressiveness. When facing the difficulties of prostate cancer diagnosis, the expression of MMPs and TIMP-3 in negative biopsies could be helpful to evaluate a diagnostic suspicion. Our objective is to carry out a comparative study of the expression of MMPs and TIMP-3 in previous negative biopsies and radical prostatectomies (RP). MATERIAL AND

METHODS:

Retrospective analysis of a hospital-based cohort including 21 patients with suspicion of prostate carcinoma, whose expressions of MMP-2, 9, 11 and 13 and TIMP-3 were evaluated by immunohistochemistry in the tumor area from previous negative biopsies and RP.

RESULTS:

Immunohistochemical staining values (Score) for MMPs (-11 and -13) and TIMP-3 showed no significant differences when comparing the areas of negative biopsies where tumors subsequently developed with those of the RP. However, we did observe a significant difference in the increased expression of MMP-2 (P=.002) and MMP-9 (P=.001) in the tumor area of the RP with respect to the corresponding area of the previous negative biopsy.

CONCLUSIONS:

Our data indicate a higher overall expression of MMP-2 and MMP-9 in the tumor area of the RP compared to the corresponding areas of the negative previous biopsy, which seems to be associated to the process of malignant transformation.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Inibidor Tecidual de Metaloproteinase-3 / Metaloproteases Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Humans / Male / Middle aged Idioma: En / Es Revista: Actas Urol Esp (Engl Ed) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Inibidor Tecidual de Metaloproteinase-3 / Metaloproteases Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Humans / Male / Middle aged Idioma: En / Es Revista: Actas Urol Esp (Engl Ed) Ano de publicação: 2020 Tipo de documento: Article