The antioxidant vitamin E as a membrane raft modulator: Tocopherols do not abolish lipid domains.
Biochim Biophys Acta Biomembr
; 1862(8): 183189, 2020 08 01.
Article
em En
| MEDLINE
| ID: mdl-31954106
ABSTRACT
The antioxidant vitamin E is a commonly used vitamin supplement. Although the multi-billion dollar vitamin and nutritional supplement industry encourages the use of vitamin E, there is very little evidence supporting its actual health benefits. Moreover, vitamin E is now marketed as a lipid raft destabilizing anti-cancer agent, in addition to its antioxidant behaviour. Here, we studied the influence of vitamin E and some of its vitamers on membrane raft stability using phase separating unilamellar lipid vesicles in conjunction with small-angle scattering techniques and fluorescence microscopy. We find that lipid phase behaviour remains unperturbed well beyond physiological concentrations of vitamin E (up to a mole fraction of 0.10). Our results are consistent with a proposed line active role of vitamin E at the domain boundary. We discuss the implications of these findings as they pertain to lipid raft modification in native membranes, and propose a new hypothesis for the antioxidant mechanism of vitamin E.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Microdomínios da Membrana
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Metabolismo dos Lipídeos
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Biomembr
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Canadá