[Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43âkDa (TDP-43) inclusions].

Kasahara, Sou; Ishihara, Tomohiko; Koike, Yuka; Sugai, Akihiro; Onodera, Osamu

[Molecular mechanism of amyotrophic lateral sclerosis (ALS) from the viewpoint of the formation and degeneration of transactive response DNA-binding protein 43âkDa (TDP-43) inclusions].

Kasahara, Sou; Ishihara, Tomohiko; Koike, Yuka; Sugai, Akihiro; Onodera, Osamu.

Afiliação

Kasahara S; Department of Neurology, Brain Research Institute, Niigata University.
Ishihara T; Department of Neurology, Brain Research Institute, Niigata University.
Koike Y; Department of Neurology, Brain Research Institute, Niigata University.
Sugai A; Department of Neurology, Brain Research Institute, Niigata University.
Onodera O; Department of Neurology, Brain Research Institute, Niigata University.

Rinsho Shinkeigaku ; 60(2): 109-116, 2020 Feb 27.

Article em Ja | MEDLINE | ID: mdl-31956195

Assuntos

Esclerose Lateral Amiotrófica/genética; Proteínas de Ligação a DNA; Autofagia; Proteína C9orf72; Proteínas de Ligação a DNA/metabolismo; Humanos; Complexo de Endopeptidases do Proteassoma; Agregação Patológica de Proteínas; Proteína FUS de Ligação a RNA; Ubiquitina

Palavras-chave

TDP-43; aggregate degradation; amyorophic lateral sclerosis; inclusion body formation; molecular pathogenesis

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a DNA / Esclerose Lateral Amiotrófica Limite: Humans Idioma: Ja Revista: Rinsho Shinkeigaku Ano de publicação: 2020 Tipo de documento: Article

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