Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I<sub>bk,Ca</sub>).

Horváth, András; Christ, Torsten; Koivumäki, Jussi T; Prondzynski, Maksymilian; Zech, Antonia T L; Spohn, Michael; Saleem, Umber; Mannhardt, Ingra; Ulmer, Bärbel; Girdauskas, Evaldas; Meyer, Christian; Hansen, Arne; Eschenhagen, Thomas; Lemoine, Marc D

Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I_bk,Ca).

Horváth, András; Christ, Torsten; Koivumäki, Jussi T; Prondzynski, Maksymilian; Zech, Antonia T L; Spohn, Michael; Saleem, Umber; Mannhardt, Ingra; Ulmer, Bärbel; Girdauskas, Evaldas; Meyer, Christian; Hansen, Arne; Eschenhagen, Thomas; Lemoine, Marc D.

Afiliação

Horváth A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Christ T; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Koivumäki JT; Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, 6721 Szeged, Hungary.
Prondzynski M; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Zech ATL; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Spohn M; BioMediTech, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.
Saleem U; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Mannhardt I; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Ulmer B; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Girdauskas E; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Meyer C; Bioinformatics Core, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hansen A; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Eschenhagen T; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Lemoine MD; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Cells ; 9(1)2020 01 20.

Article em En | MEDLINE | ID: mdl-31968557

Assuntos

Potenciais de Ação; Artefatos; Células-Tronco Pluripotentes Induzidas/metabolismo; Miócitos Cardíacos/metabolismo; Canais de Potássio Cálcio-Ativados/metabolismo; Potenciais de Ação/fisiologia; Adulto; Linhagem Celular; Simulação por Computador; Humanos; Peptídeos/toxicidade; Engenharia Tecidual

Palavras-chave

KCa1.1; Maxi-K; big conductance calcium activated potassium channel (BK); human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs); iPS cells; iberiotoxin; long QT syndrome; slo1; stem cells

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Potenciais de Ação / Artefatos / Canais de Potássio Cálcio-Ativados / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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