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The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes.
Zhang, Yong; Yang, He; Turra, David; Zhou, Shiguo; Ayhan, Dilay Hazal; DeIulio, Gregory A; Guo, Li; Broz, Karen; Wiederhold, Nathan; Coleman, Jeffrey J; Donnell, Kerry O'; Youngster, Ilan; McAdam, Alexander J; Savinov, Sergey; Shea, Terrance; Young, Sarah; Zeng, Qiandong; Rep, Martijn; Pearlman, Eric; Schwartz, David C; Di Pietro, Antonio; Kistler, H Corby; Ma, Li-Jun.
Afiliação
  • Zhang Y; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, 01003, USA.
  • Yang H; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, 01003, USA.
  • Turra D; Departamento de Genetica, Universidad de Cordoba, 14071, Cordoba, Spain.
  • Zhou S; Laboratory for Molecular and Computational Genomics, Laboratory of Genetics and Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.
  • Ayhan DH; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, 01003, USA.
  • DeIulio GA; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, 01003, USA.
  • Guo L; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, 01003, USA.
  • Broz K; School of Electronics and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
  • Wiederhold N; USDA ARS Cereal Disease Laboratory, University of Minnesota, St. Paul, Minnesota, 55108, USA.
  • Coleman JJ; Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA.
  • Donnell KO; Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama, 36849, USA.
  • Youngster I; National Center for Agricultural Utilization Research, US Department of Agriculture, Agricultural Research Service, Peoria, Illinois, 61604, USA.
  • McAdam AJ; Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, 02115, USA.
  • Savinov S; Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, 02115, USA.
  • Shea T; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, Massachusetts, 01003, USA.
  • Young S; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, 02114, USA.
  • Zeng Q; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, 02114, USA.
  • Rep M; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, 02114, USA.
  • Pearlman E; Swammerdam Institute for Life Science, University of Amsterdam, Amsterdam, The Netherlands.
  • Schwartz DC; Institute for Immunology, Physiology and Biophysics, University of California-Irvine, Irvine, California, 92697, USA.
  • Di Pietro A; Laboratory for Molecular and Computational Genomics, Laboratory of Genetics and Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.
  • Kistler HC; Departamento de Genetica, Universidad de Cordoba, 14071, Cordoba, Spain.
  • Ma LJ; USDA ARS Cereal Disease Laboratory, University of Minnesota, St. Paul, Minnesota, 55108, USA.
Commun Biol ; 3(1): 50, 2020 01 31.
Article em En | MEDLINE | ID: mdl-32005944
ABSTRACT
Fusarium oxysporum is a cross-kingdom fungal pathogen that infects plants and humans. Horizontally transferred lineage-specific (LS) chromosomes were reported to determine host-specific pathogenicity among phytopathogenic F. oxysporum. However, the existence and functional importance of LS chromosomes among human pathogenic isolates are unknown. Here we report four unique LS chromosomes in a human pathogenic strain NRRL 32931, isolated from a leukemia patient. These LS chromosomes were devoid of housekeeping genes, but were significantly enriched in genes encoding metal ion transporters and cation transporters. Homologs of NRRL 32931 LS genes, including a homolog of ceruloplasmin and the genes that contribute to the expansion of the alkaline pH-responsive transcription factor PacC/Rim1p, were also present in the genome of NRRL 47514, a strain associated with Fusarium keratitis outbreak. This study provides the first evidence, to our knowledge, for genomic compartmentalization in two human pathogenic fungal genomes and suggests an important role of LS chromosomes in niche adaptation.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Infecções Oportunistas / Cromossomos Fúngicos / Genoma Fúngico / Fusariose / Fusarium Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Commun Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Infecções Oportunistas / Cromossomos Fúngicos / Genoma Fúngico / Fusariose / Fusarium Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Commun Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos