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Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium.
Iwasaki, Keitaro; Iwasaki, Arihiro; Sumimoto, Shimpei; Matsubara, Teruhiko; Sato, Toshinori; Nozaki, Tomoyoshi; Saito-Nakano, Yumiko; Suenaga, Kiyotake.
Afiliação
  • Iwasaki K; Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • Iwasaki A; Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • Sumimoto S; Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • Matsubara T; Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • Sato T; Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-0033 , Japan.
  • Saito-Nakano Y; Department of Parasitology , National Institute of Infectious Diseases , 1-23-1 Toyama , Shinjuku-ku, Tokyo 162-8640 , Japan.
  • Suenaga K; Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
J Nat Prod ; 83(2): 481-488, 2020 02 28.
Article em En | MEDLINE | ID: mdl-32040324
ABSTRACT
An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 µM without cytotoxicity against human cancer cell lines at 10 µM.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Cianobactérias / Lipopeptídeos / Antimaláricos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Cianobactérias / Lipopeptídeos / Antimaláricos Limite: Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão