Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes.

Bi, Sixue; Huang, Weijuan; Chen, Shan; Huang, Chunhua; Li, Chunlei; Guo, Zhongyi; Yang, Jianing; Zhu, Jianhua; Song, Liyan; Yu, Rongmin

Bi, Sixue; Huang, Weijuan; Chen, Shan; Huang, Chunhua; Li, Chunlei; Guo, Zhongyi; Yang, Jianing; Zhu, Jianhua; Song, Liyan; Yu, Rongmin.

Afiliação

Bi S; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Huang W; Biotechnological Institute of Chinese Materia Medica, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Chen S; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Huang C; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Li C; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Guo Z; Biotechnological Institute of Chinese Materia Medica, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Yang J; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.
Zhu J; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: tzhujh@jnu.edu.cn.
Song L; Department of Pharmacology, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: tsly@jnu.edu.cn.
Yu R; Biotechnological Institute of Chinese Materia Medica, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China; Department of Natural Products Chemistry, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: tyrm@jnu.edu.cn.

Int J Biol Macromol ; 150: 261-280, 2020 May 01.

Article em En | MEDLINE | ID: mdl-32044366

Assuntos

Cordyceps/química; Polissacarídeos Fúngicos/farmacologia; Ativação Linfocitária/efeitos dos fármacos; Macrófagos/efeitos dos fármacos; Macrófagos/fisiologia; Transdução de Sinais/efeitos dos fármacos; Linfócitos T/efeitos dos fármacos; Linfócitos T/fisiologia; Animais; Antígeno B7-H1/metabolismo; Biomarcadores; Cálcio/metabolismo; Linhagem Celular; Citocinas/metabolismo; Polissacarídeos Fúngicos/química; Humanos; Imunomodulação; Imunofenotipagem; Ativação de Macrófagos/efeitos dos fármacos; Ativação de Macrófagos/imunologia; Camundongos; Óxido Nítrico/metabolismo; Receptor de Morte Celular Programada 1/metabolismo; Macrófagos Associados a Tumor/imunologia; Macrófagos Associados a Tumor/metabolismo; Macrófagos Associados a Tumor/patologia

Palavras-chave

Cordyceps militaris polysaccharide; PD-L1/PD-1; TLR2; Tumour-associated macrophages

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tratamento Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T / Transdução de Sinais / Cordyceps / Polissacarídeos Fúngicos / Macrófagos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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