Striatal hypofunction as a neural correlate of mood alterations in chronic pain patients.
Neuroimage
; 211: 116656, 2020 05 01.
Article
em En
| MEDLINE
| ID: mdl-32068162
ABSTRACT
BACKGROUND:
Chronic pain and mood disorders share common neuroanatomical substrates involving disruption of the reward system. Although increase in negative affect (NA) and decrease in positive affect (PA) are well-known factors complicating the clinical presentation of chronic pain patients, our understanding of the mechanisms underlying the interaction between pain and PA/NA remains limited. Here, we used a validated task probing behavioral and neural responses to monetary rewards and losses in conjunction with functional magnetic resonance imaging (fMRI) to test the hypothesis that dysfunction of the striatum, a key mesolimbic structure involved in the encoding of motivational salience, relates to mood alterations comorbid with chronic pain.METHODS:
Twenty-eight chronic musculoskeletal pain patients (chronic low back pain, n=15; fibromyalgia, n=13) and 18 healthy controls underwent fMRI while performing the Monetary Incentive Delay (MID) task. Behavioral and neural responses were compared across groups and correlated against measures of depression (Beck Depression Inventory) and hedonic capacity (Snaith-Hamilton Pleasure Scale).RESULTS:
Compared to controls, patients demonstrated higher anhedonia and depression scores, and a dampening of striatal activation and incentive-related behavioral facilitation (reduction in reaction times) during reward and loss trials of the MID task (ps â< â0.05). In all participants, lower activation of the right striatum during reward trials was correlated with lower incentive-related behavioral facilitation and higher anhedonia scores (ps â< â0.05). Finally, among patients, lower bilateral striatal activation during loss trials was correlated with higher depression scores (ps â< â0.05).CONCLUSIONS:
In chronic pain, PA reduction and NA increase are accompanied by striatal hypofunction as measured by the MID task.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Mapeamento Encefálico
/
Fibromialgia
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Dor Lombar
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Corpo Estriado
/
Depressão
/
Anedonia
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Dor Crônica
/
Desvalorização pelo Atraso
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Neuroimage
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos