The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation.

Fleischhacker, Angela S; Gunawan, Amanda L; Kochert, Brent A; Liu, Liu; Wales, Thomas E; Borowy, Maelyn C; Engen, John R; Ragsdale, Stephen W

Fleischhacker, Angela S; Gunawan, Amanda L; Kochert, Brent A; Liu, Liu; Wales, Thomas E; Borowy, Maelyn C; Engen, John R; Ragsdale, Stephen W.

Afiliação

Fleischhacker AS; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0606.
Gunawan AL; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0606.
Kochert BA; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115.
Liu L; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0606.
Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115.
Borowy MC; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0606.
Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115.
Ragsdale SW; Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-0606. Electronic address: sragsdal@umich.edu.

J Biol Chem ; 295(16): 5177-5191, 2020 04 17.

Article em En | MEDLINE | ID: mdl-32152224

Assuntos

Domínio Catalítico; Heme Oxigenase (Desciclizante)/química; Heme/metabolismo; Heme/química; Heme Oxigenase (Desciclizante)/metabolismo; Humanos; Espectrometria de Massa com Troca Hidrogênio-Deutério; Ferro/química; Ferro/metabolismo; Simulação de Dinâmica Molecular

Palavras-chave

conformational change; enzyme kinetics; enzyme mechanism; heme oxygenase; heme-binding site; heme-regulatory motif; hydrogen exchange mass spectrometry; hydrogen-deuterium exchange mass spectrometry (HDX-MS); intramolecular interaction; membrane protein; metalloprotein; protein dynamics; protein-protein interaction

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Domínio Catalítico / Heme / Heme Oxigenase (Desciclizante) Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article

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