Long-Term Survival, Health, Social Functioning, and Education in Patients With an Enterovirus Central Nervous System Infection, Denmark, 1997-2016.
J Infect Dis
; 222(4): 619-627, 2020 07 23.
Article
em En
| MEDLINE
| ID: mdl-32236420
ABSTRACT
BACKGROUND:
The long-term clinical course of patients with an enterovirus central nervous system infection (ECI) is poorly understood.METHODS:
We performed a nationwide population-based cohort study of all Danish patients with ECI diagnosed 1997-2016 (nâ =â 1745) and a comparison cohort from the general population individually matched on date of birth and sex (nâ =â 17â 450). Outcomes were categorized into mortality and risk of cancer and likely measures of neurological sequelae neuropsychiatric morbidities, educational landmarks, use of hospital services, employment, receipt of disability pension, income, number of sick leave days, and nursing home residency.RESULTS:
Mortality in the first year was higher among patients with ECI (mortality rate ratioâ [MRR] =â 10.0; 95% confidence interval [CI], 4.17-24.1), but thereafter mortality was not higher (MMRâ =â 0.94; 95% CI, 0.47-1.86). Long-term outcomes for patients with ECI were not inferior to those of the comparison cohort for risk of cancer, epilepsy, mental and behavioral disorders, dementia, depression, school start, school marks, high school education, use of hospital services, employment, receipt of disability pension, income, days of sick leave, or nursing home residency.CONCLUSIONS:
Diagnosis of an ECI had no substantial impact on long-term survival, health, or social/educational functioning.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Infecções do Sistema Nervoso Central
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Pessoas com Deficiência
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Sobreviventes
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Emprego
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Infecções por Enterovirus
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
/
Child
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Child, preschool
/
Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Dinamarca