Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy.

Hardman, Clayton; Ho, Stephen; Shimizu, Akira; Luu-Nguyen, Quang; Sloane, Jack L; Soliman, Mohamed S A; Marsden, Matthew D; Zack, Jerome A; Wender, Paul A

Hardman, Clayton; Ho, Stephen; Shimizu, Akira; Luu-Nguyen, Quang; Sloane, Jack L; Soliman, Mohamed S A; Marsden, Matthew D; Zack, Jerome A; Wender, Paul A.

Afiliação

Hardman C; Departments of Chemistry and of Chemical and Systems Biology, Stanford University, Stanford, CA, 94305, USA.
Ho S; Departments of Chemistry and of Chemical and Systems Biology, Stanford University, Stanford, CA, 94305, USA.
Shimizu A; Departments of Chemistry and of Chemical and Systems Biology, Stanford University, Stanford, CA, 94305, USA.
Luu-Nguyen Q; Departments of Chemistry and of Chemical and Systems Biology, Stanford University, Stanford, CA, 94305, USA.
Sloane JL; Departments of Chemistry and of Chemical and Systems Biology, Stanford University, Stanford, CA, 94305, USA.
Soliman MSA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Marsden MD; Division of Hematology and Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. mmarsden@ucla.edu.
Zack JA; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jzack@ucla.edu.
Wender PA; Division of Hematology and Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jzack@ucla.edu.

Nat Commun ; 11(1): 1879, 2020 04 20.

Article em En | MEDLINE | ID: mdl-32312992

Assuntos

Briostatinas/biossíntese; Briostatinas/farmacologia; Imunoterapia/métodos; Neoplasias/tratamento farmacológico; Proteína Quinase C/metabolismo; Briostatinas/química; Linhagem Celular Tumoral; Humanos; Leucemia/tratamento farmacológico; Modelos Moleculares; Lectina 2 Semelhante a Ig de Ligação ao Ácido Siálico/metabolismo; Linfócitos T

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Briostatinas / Imunoterapia / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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