Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.

Zhou, Haohan; Yuan, Danni; Gao, Weinan; Tian, Jiayi; Sun, Hongyu; Yu, Shuang; Wang, Jincheng; Sun, Liankun

Zhou, Haohan; Yuan, Danni; Gao, Weinan; Tian, Jiayi; Sun, Hongyu; Yu, Shuang; Wang, Jincheng; Sun, Liankun.

Afiliação

Zhou H; Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Yuan D; Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Gao W; Department of Orthopedics, Second Hospital, Jilin University, Changchun, China.
Tian J; Department of Reproductive Medicine and Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China.
Sun H; Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Yu S; Department of Reproductive Medicine, Second Hospital, Jilin University, Changchun, China.
Wang J; Department of Orthopedics, Second Hospital, Jilin University, Changchun, China.
Sun L; Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, China.

IUBMB Life ; 72(8): 1659-1679, 2020 08.

Article em En | MEDLINE | ID: mdl-32353215

Assuntos

Serina Peptidase 2 de Requerimento de Alta Temperatura A/genética; Biogênese de Organelas; Sarcopenia/genética; Idoso; Idoso de 80 Anos ou mais; Animais; Núcleo Celular/genética; Complexo de Proteínas da Cadeia de Transporte de Elétrons/genética; Homeostase/genética; Humanos; Masculino; Camundongos; Camundongos Knockout; Mitocôndrias/genética; Músculo Esquelético/metabolismo; Músculo Esquelético/patologia; Sarcopenia/metabolismo; Sarcopenia/patologia; Temperatura; Resposta a Proteínas não Dobradas/genética

Palavras-chave

HtrA2/Omi; UPRmt; mitochondrial biogenesis; mitohormesis; mitonuclear imbalance; sarcopenia

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Biogênese de Organelas / Sarcopenia / Serina Peptidase 2 de Requerimento de Alta Temperatura A Limite: Aged / Aged80 / Animals / Humans / Male Idioma: En Revista: IUBMB Life Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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