p53 dependent LGR5 inhibition and caspase 3 activation are critically involved in apoptotic effect of compound K and its combination therapy potential in HCT116 cells.

Pak, Ji-Na; Jung, Ji Hoon; Park, Ji Eon; Hwang, Jisung; Lee, Hyo Jung; Shim, Bum-Sang; Kim, Sung-Hoon

Pak, Ji-Na; Jung, Ji Hoon; Park, Ji Eon; Hwang, Jisung; Lee, Hyo Jung; Shim, Bum-Sang; Kim, Sung-Hoon.

Afiliação

Pak JN; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Jung JH; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Park JE; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Hwang J; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Lee HJ; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Shim BS; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Kim SH; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Phytother Res ; 34(10): 2745-2755, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32403193

Assuntos

Caspase 3/metabolismo; Neoplasias Colorretais/genética; Ginsenosídeos/uso terapêutico; Células HCT116/metabolismo; Receptores Acoplados a Proteínas G/antagonistas & inibidores; Proteína Supressora de Tumor p53/metabolismo; Apoptose; Linhagem Celular Tumoral; Neoplasias Colorretais/patologia; Ginsenosídeos/farmacologia; Humanos

Palavras-chave

LGR5; apoptosis; colorectal cancer; compound K; p53

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína Supressora de Tumor p53 / Ginsenosídeos / Células HCT116 / Receptores Acoplados a Proteínas G / Caspase 3 Limite: Humans Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2020 Tipo de documento: Article

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