Synthesis and biological evaluation of novel 1,3,4-thiadiazole derivatives as possible anticancer agents.

Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Saglik, Begüm Nurpelin; Çavusoglu, Betül Kaya; Karaduman, Abdullah Burak; Özkay, Yusuf; Kaplancikli, Zafer Asim

Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Saglik, Begüm Nurpelin; Çavusoglu, Betül Kaya; Karaduman, Abdullah Burak; Özkay, Yusuf; Kaplancikli, Zafer Asim.

Afiliação

Çevik UA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, 26470 EskisehirTurkey.
Osmaniye D; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University 26470 Eskisehir, Turkey.
Levent S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, 26470 EskisehirTurkey.
Saglik BN; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University 26470 Eskisehir, Turkey.
Çavusoglu BK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, 26470 EskisehirTurkey.
Karaduman AB; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University 26470 Eskisehir, Turkey.
Özkay Y; Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, 26470 EskisehirTurkey.
Kaplancikli ZA; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University 26470 Eskisehir, Turkey.

Acta Pharm ; 70(4): 499-513, 2020 Dec 01.

Article em En | MEDLINE | ID: mdl-32412436

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Tiadiazóis/síntese química; Tiadiazóis/farmacologia; Células A549; Animais; Inibidores da Aromatase/síntese química; Inibidores da Aromatase/farmacologia; Sobrevivência Celular/efeitos dos fármacos; Cisplatino/farmacologia; Desenho de Fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Células MCF-7; Camundongos; Células NIH 3T3; Relação Estrutura-Atividade; Sais de Tetrazólio; Tiazóis

Palavras-chave

1; 3; 4-thiadiazole; MTT assay; anticancer activity; aromatase inhibitory activity

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Tiadiazóis / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Acta Pharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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