Your browser doesn't support javascript.
loading
Antiparasitic, anti-inflammatory and cytotoxic activities of 2D coordination polymers based on 1H-indazole-5-carboxylic acid.
García-Valdivia, Antonio A; García-García, Amalia; Jannus, Fatin; Zabala-Lekuona, Andoni; Méndez-Arriaga, José M; Fernández, Belén; Medina-O'donnell, Marta; Ramírez-Rodríguez, Gloria B; Delgado-López, José M; Pastrana-Martínez, Luisa M; Cepeda, Javier; Lupiáñez, José A; Reyes-Zurita, Fernando J; Rodríguez-Diéguez, Antonio.
Afiliação
  • García-Valdivia AA; Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • García-García A; Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Jannus F; Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Zabala-Lekuona A; Departamento de Química Aplicada, Facultad de Química, Universidad del País Vasco (UPV/EHU), Paseo Manuel Lardizabal, no 3, 20018 Donostia-San Sebastián, Spain.
  • Méndez-Arriaga JM; Department of Biology and Geology, Physics and Inorganic Chemistry, Calle Tulipán s/n, 28933 Móstoles, Madrid, Spain.
  • Fernández B; Institute of Parasitology and Biomedicine "López-Neyra", CSIC, Av. Conocimiento s/n, 18600 Granada, Spain. Electronic address: belenfernandez@ipb.csic.es.
  • Medina-O'donnell M; Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Ramírez-Rodríguez GB; Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Delgado-López JM; Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Pastrana-Martínez LM; Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Cepeda J; Departamento de Química Aplicada, Facultad de Química, Universidad del País Vasco (UPV/EHU), Paseo Manuel Lardizabal, no 3, 20018 Donostia-San Sebastián, Spain.
  • Lupiáñez JA; Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain.
  • Reyes-Zurita FJ; Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain. Electronic address: ferjes@ugr.es.
  • Rodríguez-Diéguez A; Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, Av. Fuentenueva s/n, 18071 Granada, Spain. Electronic address: antonio5@ugr.es.
J Inorg Biochem ; 208: 111098, 2020 07.
Article em En | MEDLINE | ID: mdl-32454248
We report on the formation of two novel multifunctional isomorphous (4,4) square-grid 2D coordination polymers based on 1H-indazole-5-carboxylic acid. To the best of our knowledge, these complexes are the first examples of 2D-coordination polymers constructed with this novel ligand. We have analysed in detail the structural, magnetic and anti-parasitic properties of the resulting materials. In addition, the capability of inhibiting nitric oxide production from macrophage cells has been measured and was used as an indirect measure of the anti-inflammatory response. Finally, the photocatalytic activity was measured with a model pollutant, i.e. vanillic acid (phenolic compound), with the aim of further increasing the functionalities and applicability of the compounds.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Citotoxinas / Complexos de Coordenação / Indazóis / Leishmania / Anti-Inflamatórios / Antiprotozoários Limite: Animals Idioma: En Revista: J Inorg Biochem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Citotoxinas / Complexos de Coordenação / Indazóis / Leishmania / Anti-Inflamatórios / Antiprotozoários Limite: Animals Idioma: En Revista: J Inorg Biochem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha