Deletion mutant of PGE<sub>2</sub> receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua.

Kim, Yonggyun; Ahmed, Shabbir; Al Baki, Md Abdullah; Kumar, Sunil; Kim, Kunwoo; Park, Youngjin; Stanley, David

Deletion mutant of PGE₂ receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua.

Kim, Yonggyun; Ahmed, Shabbir; Al Baki, Md Abdullah; Kumar, Sunil; Kim, Kunwoo; Park, Youngjin; Stanley, David.

Afiliação

Kim Y; Department of Plant Medicals, College of Life Sciences, Andong National University, Andong 36729, South Korea. Electronic address: hosanna@anu.ac.kr.
Ahmed S; Department of Plant Medicals, College of Life Sciences, Andong National University, Andong 36729, South Korea.
Al Baki MA; Department of Plant Medicals, College of Life Sciences, Andong National University, Andong 36729, South Korea.
Kumar S; Department of Plant Medicals, College of Life Sciences, Andong National University, Andong 36729, South Korea; Department of Biological Sciences, Sungkyunkwan University, Suwon, 440-746, South Korea.
Kim K; Department of Plant Medicals, College of Life Sciences, Andong National University, Andong 36729, South Korea.
Park Y; Department of Plant Medicals, College of Life Sciences, Andong National University, Andong 36729, South Korea; Plant Quarantine Technology Center, Animal and Plant Quarantine Agency, Gimcheon, 39660, South Korea.
Stanley D; Biological Control of Insect Research Laboratory, USDA/Agricultural Research Service, Colombia, MO, USA.

Dev Comp Immunol ; 111: 103743, 2020 10.

Article em En | MEDLINE | ID: mdl-32464135

Assuntos

Infecções Bacterianas/imunologia; Hemócitos/fisiologia; Proteínas de Insetos/genética; Receptores de Prostaglandina E/genética; Deleção de Sequência/genética; Spodoptera/fisiologia; Animais; Proteína 9 Associada à CRISPR/metabolismo; Sistemas CRISPR-Cas; Processos de Crescimento Celular; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Feminino; Tolerância Imunológica/genética; Imunidade Celular; Infertilidade Feminina/genética; Larva; Interferência de RNA; Reprodução; Células Sf9; Transdução de Sinais

Palavras-chave

CRISPR-Cas9; Insect; PGE(2); Receptor; Signal transduction

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Infecções Bacterianas / Deleção de Sequência / Receptores de Prostaglandina E / Spodoptera / Proteínas de Insetos / Hemócitos Limite: Animals Idioma: En Revista: Dev Comp Immunol Ano de publicação: 2020 Tipo de documento: Article

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