Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study.
BJOG
; 127(11): 1374-1380, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32479682
ABSTRACT
OBJECTIVES:
To investigate the incidence of clinical, ultrasonographic and biochemical findings related to pre-eclampsia (PE) in pregnancies with COVID-19, and to assess their accuracy to differentiate between PE and the PE-like features associated with COVID-19.DESIGN:
A prospective, observational study.SETTING:
Tertiary referral hospital.PARTICIPANTS:
Singleton pregnancies with COVID-19 at >20+0 weeks.METHODS:
Forty-two consecutive pregnancies were recruited and classified into two groups severe and non-severe COVID-19, according to the occurrence of severe pneumonia. Uterine artery pulsatility index (UtAPI) and angiogenic factors (soluble fms-like tyrosine kinase-1/placental growth factor [sFlt-1/PlGF]) were assessed in women with suspected PE. MAIN OUTCOMEMEASURES:
Incidence of signs and symptoms related to PE, such as hypertension, proteinuria, thrombocytopenia, elevated liver enzymes, abnormal UtAPI and increased sFlt-1/PlGF.RESULTS:
Thirty-four cases were classified as non-severe and 8 as severe COVID-19. Five (11.9%) women presented signs and symptoms of PE, all five being among the severe COVID-19 cases (62.5%). However, abnormal sFlt-1/PlGF and UtAPI could only be demonstrated in one case. One case remained pregnant after recovery from severe pneumonia and had a spontaneous resolution of the PE-like syndrome.CONCLUSIONS:
Pregnant women with severe COVID-19 can develop a PE-like syndrome that might be distinguished from actual PE by sFlt-1/PlGF, LDH and UtAPI assessment. Healthcare providers should be aware of its existence and monitor pregnancies with suspected pre-eclampsia with caution. TWEETABLE ABSTRACT This study shows that a pre-eclampsia-like syndrome could be present in some pregnancies with severe COVID-19.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Pré-Eclâmpsia
/
Complicações Infecciosas na Gravidez
/
Síndrome HELLP
/
Infecções por Coronavirus
/
Receptor 1 de Fatores de Crescimento do Endotélio Vascular
/
Artéria Uterina
/
Fator de Crescimento Placentário
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
BJOG
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha