EBV renders B cells susceptible to HIV-1 in humanized mice.
Life Sci Alliance
; 3(8)2020 08.
Article
em En
| MEDLINE
| ID: mdl-32576602
ABSTRACT
HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell-mediated immune control.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Herpesvirus Humano 4
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Life Sci Alliance
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suíça