Implications of NAD+ boosters in translational medicine.
Eur J Clin Invest
; 50(10): e13334, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32594513
ABSTRACT
Nicotinamide adenine dinucleotide (NAD+ ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation and cyclic ADP-ribose synthesis mediated by sirtuins, poly (ADP-ribose) polymerases (PARPs) and CD38. In eukaryotic cells, NAD+ is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD+ . The therapeutic potential of dietarily available NAD+ boosters preserving the NAD+ pool has been attracting attention after the discovery of declining NAD+ levels in ageing model organisms as well as in several age-related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD+ , including the salubrious effects of NAD+ boosters and discuss their future translational strategies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Compostos de Piridínio
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Envelhecimento
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Niacinamida
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Inibidores Enzimáticos
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Inibidores de Poli(ADP-Ribose) Polimerases
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NAD
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Mononucleotídeo de Nicotinamida
Limite:
Animals
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Humans
Idioma:
En
Revista:
Eur J Clin Invest
Ano de publicação:
2020
Tipo de documento:
Article