A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNF&#945;-Induced <i>MMP9</i> Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells.

Jeong, Munki; Jung, Euitaek; Lee, Young Han; Seo, Jeong Kon; Ahn, Seunghyun; Koh, Dongsoo; Lim, Yoongho; Shin, Soon Young

A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced MMP9 Expression via EGR-1 Downregulation in MDA-MB-231 Human Breast Cancer Cells.

Jeong, Munki; Jung, Euitaek; Lee, Young Han; Seo, Jeong Kon; Ahn, Seunghyun; Koh, Dongsoo; Lim, Yoongho; Shin, Soon Young.

Afiliação

Jeong M; Department of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.
Jung E; Department of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.
Lee YH; Department of Biological Sciences, Sanghuh College of Lifesciences, Koknkuk University, Seoul 05029, Korea.
Seo JK; Cancer and Metabolism Institute, Konkuk University, Seoul 05029, Korea.
Ahn S; UNIST Central Research Facilities, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea.
Koh D; Department of Applied Chemistry, Dongduk Women's University, Seoul 02748, Korea.
Lim Y; Department of Applied Chemistry, Dongduk Women's University, Seoul 02748, Korea.
Shin SY; Cancer and Metabolism Institute, Konkuk University, Seoul 05029, Korea.

Int J Mol Sci ; 21(14)2020 Jul 18.

Article em En | MEDLINE | ID: mdl-32708426

Assuntos

Antineoplásicos/farmacologia; Neoplasias da Mama/tratamento farmacológico; Proteína 1 de Resposta de Crescimento Precoce/metabolismo; Metaloproteinase 9 da Matriz/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Actinas/metabolismo; Neoplasias da Mama/enzimologia; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Regulação para Baixo; Feminino; Flavonoides/química; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 9 da Matriz/genética; NF-kappa B/metabolismo; Invasividade Neoplásica; Esferoides Celulares; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

(E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile; EGR-1; MDA-MB-231; MMP9; TNFα; flavonoid

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fator de Necrose Tumoral alfa / Metaloproteinase 9 da Matriz / Proteína 1 de Resposta de Crescimento Precoce / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article

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