Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine.

Sanavia, Tiziana; Birolo, Giovanni; Montanucci, Ludovica; Turina, Paola; Capriotti, Emidio; Fariselli, Piero

Sanavia, Tiziana; Birolo, Giovanni; Montanucci, Ludovica; Turina, Paola; Capriotti, Emidio; Fariselli, Piero.

Afiliação

Sanavia T; Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
Birolo G; Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
Montanucci L; Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell'Università 16, 35020 Legnaro, Italy.
Turina P; Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via F. Selmi 3, 40126 Bologna, Italy.
Capriotti E; Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via F. Selmi 3, 40126 Bologna, Italy.
Fariselli P; Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.

Comput Struct Biotechnol J ; 18: 1968-1979, 2020.

Article em En | MEDLINE | ID: mdl-32774791

Palavras-chave

Computational tools and databases; Machine learning; Mutations; Non-synonymous single nucleotide variants; Performance bias; Protein function; Protein stability

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Comput Struct Biotechnol J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália

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