Pharmacokinetics of 10B-p-boronophenylalanine (BPA) in the blood and tumors in human patients: A critical review with special reference to tumor-to-blood (T/B) ratios using resected tumor samples.
Appl Radiat Isot
; 166: 109308, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32823081
ABSTRACT
We reviewed 10B concentration kinetics in the blood and tumors in human patients administered with BPA. The 10B concentration in the blood peaked at the end of intravenous infusion of BPA, followed by a biphasic-decreasing curve with half-lives for the first and second components of the curve being 0.7-3.7 and 7.2-12.0 h, respectively. The mean tumor-to-blood (T/B) ratio obtained from resected tumor samples was 3.40 ± 0.83 for melanoma and the ratio ranged from 1.4 to 4.7 for glioblastoma.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
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Outros_tipos
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Tratamento
/
Radioterapia
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
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Compostos de Boro
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Terapia por Captura de Nêutron de Boro
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Neoplasias
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Appl Radiat Isot
Assunto da revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Ano de publicação:
2020
Tipo de documento:
Article