Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20.

Lammerts, Rosa G M; Talsma, Ditmer T; Dam, Wendy A; Daha, Mohamed R; Seelen, Marc A J; Berger, Stefan P; van den Born, Jacob

Lammerts, Rosa G M; Talsma, Ditmer T; Dam, Wendy A; Daha, Mohamed R; Seelen, Marc A J; Berger, Stefan P; van den Born, Jacob.

Afiliação

Lammerts RGM; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Talsma DT; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Dam WA; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Daha MR; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Seelen MAJ; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Berger SP; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
van den Born J; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Front Immunol ; 11: 1643, 2020.

Article em En | MEDLINE | ID: mdl-32849563

Assuntos

Complemento C3b/metabolismo; Inativadores do Complemento/farmacologia; Células Epiteliais/efeitos dos fármacos; Heparitina Sulfato/metabolismo; Proteínas de Insetos/farmacologia; Túbulos Renais Proximais/efeitos dos fármacos; Properdina/metabolismo; Receptores de Reconhecimento de Padrão/metabolismo; Proteínas e Peptídeos Salivares/farmacologia; Sindecana-1/metabolismo; Animais; Linhagem Celular; Ativação do Complemento/efeitos dos fármacos; Células Epiteliais/metabolismo; Humanos; Ixodes; Túbulos Renais Proximais/metabolismo; Peptídeos Cíclicos/farmacologia; Ligação Proteica; Transdução de Sinais; Sindecana-1/genética

Palavras-chave

C3; Salp20; complement; properdin; syndecan-1

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas e Peptídeos Salivares / Properdina / Complemento C3b / Proteínas de Insetos / Células Epiteliais / Receptores de Reconhecimento de Padrão / Inativadores do Complemento / Sindecana-1 / Heparitina Sulfato / Túbulos Renais Proximais Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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