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The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital.
Lazareva, Irina; Ageevets, Vladimir; Sopova, Julia; Lebedeva, Marina; Starkova, Polina; Likholetova, Daria; Lebedeva, Maria; Gostev, Vladimir; Moiseenko, Vladimir; Egorenkov, Vitaliy; Navatskaya, Arina; Mitroshina, Galina; Myasnikova, Elena; Tsvetkova, Irina; Lobzin, Yuri; Sidorenko, Sergey.
Afiliação
  • Lazareva I; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia.
  • Ageevets V; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia.
  • Sopova J; Saint Petersburg University, Universitetskaya Emb. 13B, Saint Petersburg 199034, Russia.
  • Lebedeva M; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia.
  • Starkova P; National Research Institute of Information Technologies, Mechanics and Optics, Lomonosova Str. 9, Saint Petersburg 191002, Russia.
  • Likholetova D; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; Saint Petersburg University, Universitetskaya Emb. 13B, Saint Petersburg 199034, Russia.
  • Lebedeva M; Bryansk Interregional Veterinary Laboratory, Suponevo, Shosseynaya Str. 7, Bryansk 241520, Russia.
  • Gostev V; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia.
  • Moiseenko V; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia.
  • Egorenkov V; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia.
  • Navatskaya A; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia.
  • Mitroshina G; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia.
  • Myasnikova E; Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic), Posolok Pesochnyy, Leningradskaya Str. 68А, Saint Petersburg 197758, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia.
  • Tsvetkova I; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia.
  • Lobzin Y; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia.
  • Sidorenko S; Pediatric Research and Clinical Center for Infectious Diseases, Professor Popov Str. 9, Saint Petersburg 197022, Russia; North-Western State Medical University named after I.I. Mechnikov, Kirochnaya street, 41, Saint Petersburg 191015, Russia. Electronic address: sidorserg@niidi.ru.
Infect Genet Evol ; 85: 104527, 2020 11.
Article em En | MEDLINE | ID: mdl-32898687
Fifteen hypermucoviscous isolates (13 blaNDM-1-positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD50 = 102 CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD50 = 104 CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD50 = 105 CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Virulência / Beta-Lactamases / Infecções por Klebsiella / Farmacorresistência Bacteriana / Klebsiella pneumoniae / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Infect Genet Evol Assunto da revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Virulência / Beta-Lactamases / Infecções por Klebsiella / Farmacorresistência Bacteriana / Klebsiella pneumoniae / Antibacterianos Limite: Animals / Humans Idioma: En Revista: Infect Genet Evol Assunto da revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Federação Russa