[Prevention of deep venous thrombosis with defibrotide in chest surgery. Controlled multicenter study versus heparin]. / Profilassi con defibrotide delle trombosi venose profonde in chirurgia toracica. Studio multicentrico controllato verso eparina.
Minerva Med
; 78(11): 745-50, 1987 Jun 15.
Article
em It
| MEDLINE
| ID: mdl-3295599
ABSTRACT
The effectiveness and tolerability of defibrotide in the prevention of post-surgery deep vein thrombosis (DVT) were compared with those of heparin in a multicentric randomized controlled study. One hundred-eight-four both sexes patients submitted to thoracic surgery were randomly allocated to defibrotide (400 mg b.i.d. by IV route, n = 94) or to calcium heparin (5000 I.U. t.i.d. s.c., n = 90); both treatments were started the day before the operation and withdrawn when patients were allowed to stand up (i.e., after 7 days). No patients developed DVT in the defibrotide group, while a single case of DVT was detected in the heparin group; furthermore, a more prominent bleeding was observed in the latter, in the early post-operative period (normal bleeding 2nd day defibrotide 70/92 pts, heparin 53/90 pts, p less than 0.02; 3rd day defibrotide 87/92 pts, heparin 76/90 pts, p less than 0.05, chi 2 test), while the healing rate of surgical wounds was similar in the two groups. No relevant modifications in laboratory parameters were seen throughout the observation period. Thus, these preliminary data suggest that defibrotide is at least as effective as heparin in the prevention of post-thoracic surgery DVT and that the former drug has a possibly better tolerability profile, due to a lesser tendency to bleeding.
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Coleções:
01-internacional
Temas:
Geral
/
Cirurgia_oncologica
Base de dados:
MEDLINE
Assunto principal:
Polidesoxirribonucleotídeos
/
Cirurgia Torácica
/
Tromboflebite
/
Heparina
/
Fibrinolíticos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
It
Revista:
Minerva Med
Ano de publicação:
1987
Tipo de documento:
Article