Short-term changes in left and right systolic function following ferric carboxymaltose: a substudy of the Myocardial-IRON trial.
ESC Heart Fail
; 7(6): 4222-4230, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33040491
ABSTRACT
AIMS:
The mechanisms underlying the beneficial effect of ferric carboxymaltose (FCM) in patients with heart failure (HF) and iron deficiency (ID) have not been completely characterized. The Myocardial-IRON trial was a double-blind, randomized trial that evaluated myocardial iron repletion following FCM vs. placebo in 53 patients with HF and ID. In this post hoc analysis, we evaluated whether treatment with FCM was associated with cardiac magnetic resonance changes in left and right ventricular function (LVEF and RVEF, respectively) at different points of systolic dysfunction. METHODS ANDRESULTS:
We included patients from the Myocardial-IRON trial with left and right ventricular systolic dysfunction (LVSD and RVSD, respectively) at enrolment. Linear mixed regression models were used to evaluate changes at 7 and 30 days on LVEF and RVEF at cardiac magnetic resonance. At enrolment, 27 (50.9%) and 38 (71.7%) patients had LVEF < 40% (LVSD1 ) or <45% (LVSD2 ), respectively, and 10 (18.9%) and 17 (32.1%) patients had RVEF < 45% (RVSD1 ) or <51% in women and <52% in men (RVSD2) , respectively. Treatment with FCM was associated with a significant improvement in LVEF at 30 days (LVSD1 Δ2.3%, P < 0.001; LVSD2 Δ4.1, P = 0.014). FCM was also associated with a significant and early improvement in RVEF at 7 days (RVSD1 Δ6.9%, P = 0.003; RVSD2 Δ3.2%, P = 0.003) that persisted at 30 days (RVSD1 Δ8.1%, P < 0.001; RVSD2 Δ4.7%, P < 0.001).CONCLUSIONS:
In patients with HF and systolic dysfunction with ID, FCM was associated with short-term improvement in LVEF and, especially, in RVEF.
Texto completo:
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Coleções:
01-internacional
Temas:
Agentes_cancerigenos
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
Idioma:
En
Revista:
ESC Heart Fail
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha