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Asperochratides A-J, Ten new polyketides from the deep-sea-derived Aspergillus ochraceus.
Zou, Zheng-Biao; Zhang, Gang; Li, Su-Mei; He, Zhi-Hui; Yan, Qing-Xiang; Lin, Yu-Kun; Xie, Chun-Lan; Xia, Jin-Mei; Luo, Zhu-Hua; Luo, Lian-Zhong; Yang, Xian-Wen.
Afiliação
  • Zou ZB; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Zhang G; Fujian Province Universities and Colleges Engineering Research Center for Marine Biomedical Resource Utilization, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China.
  • Li SM; Department of Pharmacology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China.
  • He ZH; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Yan QX; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Lin YK; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Xie CL; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Xia JM; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Luo ZH; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
  • Luo LZ; Fujian Province Universities and Colleges Engineering Research Center for Marine Biomedical Resource Utilization, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China. Electronic address: lzluo@xmu.edu.cn.
  • Yang XW; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China. Electronic address: yangxianwen@tio.org.cn.
Bioorg Chem ; 105: 104349, 2020 12.
Article em En | MEDLINE | ID: mdl-33074115
ABSTRACT
Ten new C9 polyketides (asperochratides A-J, 1-10) and 14 known miscellaneous compounds (11-24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher's method, Mo2(OAc)4 induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1-11 and 16-18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5-8 and 13-17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Água do Mar / Aspergillus ochraceus / Misturas Complexas / Policetídeos / Anti-Inflamatórios / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Água do Mar / Aspergillus ochraceus / Misturas Complexas / Policetídeos / Anti-Inflamatórios / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China