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Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer.
Nicolazzo, Chiara; Loreni, Flavia; Caponnetto, Salvatore; Magri, Valentina; Vestri, Anna Rita; Zamarchi, Rita; Gradilone, Angela; Facchinetti, Antonella; Rossi, Elisabetta; Cortesi, Enrico; Gazzaniga, Paola.
Afiliação
  • Nicolazzo C; Department of Molecular Medicine, Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy.
  • Loreni F; Department of Molecular Medicine, Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy.
  • Caponnetto S; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
  • Magri V; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
  • Vestri AR; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Zamarchi R; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
  • Gradilone A; Department of Molecular Medicine, Liquid Biopsy Unit, Sapienza University of Rome, Rome, Italy.
  • Facchinetti A; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
  • Rossi E; Department of Surgery, Oncology and Gastroenterology, University of Padova, Italy.
  • Cortesi E; Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
  • Gazzaniga P; Department of Surgery, Oncology and Gastroenterology, University of Padova, Italy.
Oncotarget ; 11(45): 4115-4122, 2020 Nov 10.
Article em En | MEDLINE | ID: mdl-33227095
ABSTRACT
CD44v6, the CD44 isoform mostly involved in cancer cell migration and invasion, has been identified as a functional biomarker and therapeutic target in colon cancer stem cells. We here provide evidence that baseline CD44v6-positive CTC predict treatment failure in patients with metastatic colorectal cancer undergoing first-line chemotherapy. We suggest that CD44v6-positive CTC can be used to early detect intrinsic drug resistance in this cancer type.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncotarget Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncotarget Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália