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On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
Moser, Tina; Waldispuehl-Geigl, Julie; Belic, Jelena; Weber, Sabrina; Zhou, Qing; Hasenleithner, Samantha O; Graf, Ricarda; Terzic, Jasmin Alia; Posch, Florian; Sill, Heinz; Lax, Sigurd; Kashofer, Karl; Hoefler, Gerald; Schoellnast, Helmut; Heitzer, Ellen; Geigl, Jochen B; Bauernhofer, Thomas; Speicher, Michael R.
Afiliação
  • Moser T; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Waldispuehl-Geigl J; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Belic J; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Weber S; Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE, Cambridge, UK.
  • Zhou Q; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Hasenleithner SO; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Graf R; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Terzic JA; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Posch F; Department of Internal Medicine Graz, Division of Oncology, Medical University of Graz, Graz, Austria.
  • Sill H; Department of Internal Medicine Graz, Division of Oncology, Medical University of Graz, Graz, Austria.
  • Lax S; Department of Internal Medicine, Division of Hematology, Medical University of Graz, Graz, Austria.
  • Kashofer K; Department of Pathology, General Hospital Graz II, Graz, Austria, and Johannes Kepler University Linz, Linz, Austria.
  • Hoefler G; Institute of Pathology, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Schoellnast H; Institute of Pathology, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Heitzer E; Department of Radiology, Division of General Radiology, Medical University of Graz, Graz, Austria.
  • Geigl JB; Institute of Human Genetics, Diagnostic and Research Center for Molecular BioMedicine, Medical University of Graz, Graz, Austria.
  • Bauernhofer T; BioTechMed-Graz, Graz, Austria.
  • Speicher MR; Christian Doppler Laboratory for Liquid Biopsies for Early Detection of Cancer, Graz, Austria.
NPJ Precis Oncol ; 4(1): 30, 2020 Nov 13.
Article em En | MEDLINE | ID: mdl-33299124
ABSTRACT
We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of FOLFOX. Surprisingly, we did not observe a spike in ctDNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or partial response. Our observations reveal further insights into cell destruction during chemotherapy with important implications for the management of patients.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Idioma: En Revista: NPJ Precis Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Áustria
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Colon_e_reto Base de dados: MEDLINE Idioma: En Revista: NPJ Precis Oncol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Áustria