5-Hydroxy-4-methoxycanthin-6-one alleviates dextran sodium sulfate-induced colitis in rats via regulation of metabolic profiling and suppression of NF-&#954;B/p65 signaling pathway.

Liu, Fangle; Yao, Yufeng; Lu, Zenghui; Zhang, Qiuyu; Liu, Changhui; Zhu, Chenchen; Lin, Chaozhan

5-Hydroxy-4-methoxycanthin-6-one alleviates dextran sodium sulfate-induced colitis in rats via regulation of metabolic profiling and suppression of NF-κB/p65 signaling pathway.

Liu, Fangle; Yao, Yufeng; Lu, Zenghui; Zhang, Qiuyu; Liu, Changhui; Zhu, Chenchen; Lin, Chaozhan.

Afiliação

Liu F; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Yao Y; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Lu Z; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Zhang Q; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Liu C; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Zhu C; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: zhucc@gzucm.edu.cn.
Lin C; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China. Electronic address: linchaozhan@gzucm.edu.cn.

Phytomedicine ; 82: 153438, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33422953

Assuntos

Carbolinas/química; Carbolinas/uso terapêutico; Colite/tratamento farmacológico; Sulfato de Dextrana/efeitos adversos; NF-kappa B/metabolismo; Transdução de Sinais/efeitos dos fármacos; Fator de Transcrição RelA/metabolismo; Animais; Biomarcadores/metabolismo; Colite/induzido quimicamente; Citocinas/metabolismo; Masculino; Metabolômica; Simulação de Acoplamento Molecular; Ratos; Espectrometria de Massas em Tandem

Palavras-chave

5-hydroxy-4-methoxycanthin-6-one; Metabolomics; NF-κB/p65 signaling pathway; Ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Carbolinas / Transdução de Sinais / Sulfato de Dextrana / NF-kappa B / Colite / Fator de Transcrição RelA Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2021 Tipo de documento: Article

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