Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation.

Li, Mingyu; Rehman, Ashfaq Ur; Liu, Yaqin; Chen, Kai; Lu, Shaoyong

Li, Mingyu; Rehman, Ashfaq Ur; Liu, Yaqin; Chen, Kai; Lu, Shaoyong.

Afiliação

Li M; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Rehman AU; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Liu Y; Medicinal Chemistry and Bioinformatics Centre, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Chen K; Department of Orthopedics, Changhai Hospital, Naval Military Medical University, Shanghai, China. Electronic address: ch_kai@163.com.
Lu S; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Medicinal Chemistry and Bioinformatics Centre, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Adv Protein Chem Struct Biol ; 124: 87-119, 2021.

Article em En | MEDLINE | ID: mdl-33632471

Assuntos

Trifosfato de Adenosina/química; Trifosfato de Adenosina/metabolismo; Inibidores de Proteínas Quinases/química; Proteínas Quinases/química; Proteínas Quinases/metabolismo; Regulação Alostérica; Animais; Sítios de Ligação; Humanos

Palavras-chave

ATP-binding site; Allostery; Protein kinase; Small molecule inhibitor

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Trifosfato de Adenosina / Inibidores de Proteínas Quinases Limite: Animals / Humans Idioma: En Revista: Adv Protein Chem Struct Biol Assunto da revista: BIOLOGIA / BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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