Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.

Zhao, Miao-Miao; Yang, Wei-Li; Yang, Fang-Yuan; Zhang, Li; Huang, Wei-Jin; Hou, Wei; Fan, Chang-Fa; Jin, Rong-Hua; Feng, Ying-Mei; Wang, You-Chun; Yang, Jin-Kui

Zhao, Miao-Miao; Yang, Wei-Li; Yang, Fang-Yuan; Zhang, Li; Huang, Wei-Jin; Hou, Wei; Fan, Chang-Fa; Jin, Rong-Hua; Feng, Ying-Mei; Wang, You-Chun; Yang, Jin-Kui.

Afiliação

Zhao MM; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yang WL; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yang FY; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Zhang L; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.
Huang WJ; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China.
Hou W; Department of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Fan CF; Division of Animal Model Research, Institute for Laboratory Animal Resources, National Institutes for Food and Drug Control, Beijing, China.
Jin RH; Department of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Feng YM; Department of Science and Technology, Beijing Youan Hospital, Capital Medical University, Beijing, China. yingmeif13@sina.com.
Wang YC; Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), Beijing, China. wangyc@nifdc.org.cn.
Yang JK; Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. jkyang@ccmu.edu.cn.

Signal Transduct Target Ther ; 6(1): 134, 2021 03 27.

Article em En | MEDLINE | ID: mdl-33774649

Assuntos

Antivirais/farmacologia; COVID-19/metabolismo; Catepsina L; Inibidores de Cisteína Proteinase/farmacologia; Desenvolvimento de Medicamentos; SARS-CoV-2/metabolismo; Glicoproteína da Espícula de Coronavírus/metabolismo; Internalização do Vírus/efeitos dos fármacos; Adolescente; Adulto; Idoso; Animais; COVID-19/genética; Catepsina L/antagonistas & inibidores; Catepsina L/genética; Catepsina L/metabolismo; Feminino; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Pessoa de Meia-Idade; SARS-CoV-2/genética; Glicoproteína da Espícula de Coronavírus/genética; Tratamento Farmacológico da COVID-19

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Cisteína Proteinase / Internalização do Vírus / Catepsina L / Glicoproteína da Espícula de Coronavírus / Desenvolvimento de Medicamentos / SARS-CoV-2 / COVID-19 Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Signal Transduct Target Ther Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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