Aromatase inhibitor anastrozole modifies cellular functions in gingival fibroblasts and endothelial cells: possible periodontal complications of aromatase inhibitor treatment.
J Periodontal Res
; 56(4): 828-836, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-33797064
ABSTRACT
BACKGROUND:
Recent studies have shown that treatment with aromatase inhibitors contributes to an increased prevalence of periodontitis.OBJECTIVE:
In this study, we assessed effects of the aromatase inhibitor anastrozole on cellular function of human gingival fibroblasts (HGFs) and endothelial cells.METHODS:
Expression levels of collagen, extracellular matrix (ECM) proteins, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) were examined in HGFs exposed to anastrozole. Furthermore, inflammatory responses in HGFs cultured with anastrozole were evaluated in the presence of Porphyromonas gingivalis lipopolysaccharide. We also evaluated the vascular permeability and vascular endothelial (VE)-cadherin expression of endothelial cells exposed to anastrozole.RESULTS:
Anastrozole enhanced expression levels of collagen, ECM proteins, TIMPs, and inflammatory cytokines in HGFs, as well as vascular permeability of endothelial cells. In addition, anastrozole reduced expression levels of MMPs in HGFs and VE-cadherin in endothelial cells.CONCLUSION:
These results suggest that anastrozole modulates various cellular functions in HGFs and endothelial cells.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Células Endoteliais
/
Inibidores da Aromatase
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Periodontal Res
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão