Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment.
Pharmacol Res
; 169: 105604, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33845125
ABSTRACT
Diabetes mellitus is one of the biggest health emergencies of the 21st century worldwide, characterized by deficiency in insulin secretion and/or action, leading to hyperglycemia. Despite the currently available antidiabetic therapeutic options, 4.2 million people died in 2019 due to diabetes. Thus, new effective interventions are required. Polyphenols are plant secondary metabolites and have been recognized for their vast number of biological activities, including potential antidiabetic effects. However, the poor bioavailability and high metabolization of polyphenols restrict their biological effects in vivo. Nanotechnology is a promising area of research to improve the therapeutic effect of several compounds. Therefore, this review provides an overview of the literature about the utility of nano-based drug delivery systems as vehicles of polyphenols in diabetes treatment. It was possible to conclude that, in general, nano-based drug delivery systems can potentiate the beneficial antidiabetic properties of polyphenols, when compared with the free compounds, opening a new field of research in diabetology.
Palavras-chave
Amentoflavone (PubChem CID: 5281600); Diabetes mellitus; Drug targeting; Fisetin (PubChem CID: 5281614); Gallic acid (PubChem CID: 370); Myricitrin (PubChem CID: 5281673); Nano-based drug delivery systems; Naringenin (PubChem CID: 932); Polyphenols; Quercetin (PubChem CID: 5280343); Resveratrol (PubChem CID: 445154); Rutin (PubChem CID: 5280805); Scutellarin (PubChem CID: 185617); Silybin (PubChem CID: 31553)
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
/
Sistemas de Liberação de Fármacos por Nanopartículas
/
Hipoglicemiantes
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Portugal