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Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy.
Best, Rebecca L; LaPointe, Nichole E; Azarenko, Olga; Miller, Herb; Genualdi, Christine; Chih, Stephen; Shen, Ben-Quan; Jordan, Mary Ann; Wilson, Leslie; Feinstein, Stuart C; Stagg, Nicola J.
Afiliação
  • Best RL; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • LaPointe NE; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Azarenko O; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Miller H; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Genualdi C; Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chih S; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Shen BQ; Preclinical and Translational PK, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jordan MA; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Wilson L; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.
  • Feinstein SC; Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA. Electronic address: feinstei@lifesci.ucsb.edu.
  • Stagg NJ; Safety Assessment, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: stagg.nicola@gene.com.
Toxicol Appl Pharmacol ; 421: 115534, 2021 06 15.
Article em En | MEDLINE | ID: mdl-33852878
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Tubulina (Proteína) / Neoplasias da Mama / Sistema Nervoso Periférico / Doenças do Sistema Nervoso Periférico / Moduladores de Tubulina / Microtúbulos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Tubulina (Proteína) / Neoplasias da Mama / Sistema Nervoso Periférico / Doenças do Sistema Nervoso Periférico / Moduladores de Tubulina / Microtúbulos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos