Implications of ADAM17 activation for hyperglycaemia, obesity and type 2 diabetes.
Biosci Rep
; 41(5)2021 05 28.
Article
em En
| MEDLINE
| ID: mdl-33904577
ABSTRACT
In this review, we focus specifically on the role that the metalloproteinase, A Disintegrin and Metalloproteinase 17 [ADAM17] plays in the development and progression of the metabolic syndrome. There is a well-recognised link between the ADAM17 substrate tumour necrosis factor α (TNF-α) and obesity, inflammation and diabetes. In addition, knocking out ADAM17 in mice leads to an extremely lean phenotype. Importantly, ADAM17-deficient mice exhibit one of the most pronounced examples of hypermetabolism in rodents to date. It is vital to further understand the mechanistic role that ADAM17 plays in the metabolic syndrome. Such studies will demonstrate that ADAM17 is a valuable therapeutic target to treat obesity and diabetes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
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Proteína ADAM17
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Hiperglicemia
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Obesidade
Limite:
Animals
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Humans
Idioma:
En
Revista:
Biosci Rep
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália