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Interventional Radiology Approaches for Liver Metastases from Thyroid Cancer: A Case Series and Overview of the Literature.
Nervo, Alice; Ragni, Alberto; Retta, Francesca; Calandri, Marco; Gazzera, Carlo; Gallo, Marco; Piovesan, Alessandro; Arvat, Emanuela.
Afiliação
  • Nervo A; Oncological Endocrinology Unit, Department of Medical Sciences, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy. alice.nervo@gmail.com.
  • Ragni A; Oncological Endocrinology Unit, Department of Medical Sciences, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.
  • Retta F; Oncological Endocrinology Unit, Department of Medical Sciences, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.
  • Calandri M; Diagnostic Imaging and Interventional Radiology Department, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.
  • Gazzera C; Diagnostic Imaging and Interventional Radiology Department, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.
  • Gallo M; Oncological Endocrinology Unit, Department of Medical Sciences, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.
  • Piovesan A; Endocrinology and Metabolic Diseases Unit, AO SS. Antonio E Biagio E Cesare Arrigo Hospital, Alessandria, Italy.
  • Arvat E; Oncological Endocrinology Unit, Department of Medical Sciences, Città Della Salute E Della Scienza Hospital, University of Turin, Turin, Italy.
J Gastrointest Cancer ; 52(3): 823-832, 2021 Sep.
Article em En | MEDLINE | ID: mdl-33999355
BACKGROUND: Liver metastases (LMs) from thyroid cancer (TC) are relatively uncommon in clinical practice and their management is challenging. Interventional radiology loco-regional treatments (LRTs), including radiofrequency ablation (RFA) and trans-arterial chemoembolization (TACE), have been successfully employed to treat LMs from various types of cancer. METHODS: We analyzed the role of LRTs in the management of unresectable LMs from differentiated and medullary TCs performed at our institution from 2015 to 2020. A review of the available English literature regarding this topic was also performed. RESULTS: Six hepatic LRTs were performed in 4 TC patients with LMs, in 2 cases after the start of treatment with a tyrosine kinase inhibitor (TKI). A partial response was obtained in 2 patients; the diameter of the largest targeted lesion was 18 mm in both of them. The remaining procedures were performed on larger lesions and a stable disease was achieved in all but one case. Acute LRT-related complications were transient and mild. In literature, the largest studies were focused on TACE in LMs from MTC, showing good tolerance and remarkable disease control, especially in case of limited liver tumour involvement. CONCLUSION: LRTs for LMs represent a valuable option for the treatment of metastatic TC in case of isolated hepatic progression or for symptoms relief, also after the start of TKI treatment as part of a multimodal approach. The best disease control is obtained when hepatic metastatic burden is limited. These procedures are generally well tolerated; however, a cautious multidisciplinary selection of the candidates is mandatory.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Hepáticas Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: J Gastrointest Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Hepáticas Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: J Gastrointest Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália