Identification of prognostic tumor-infiltrating immune cells in endometrial adenocarcinoma.
Medicine (Baltimore)
; 100(21): e26170, 2021 May 28.
Article
em En
| MEDLINE
| ID: mdl-34032778
ABSTRACT
ABSTRACT To identify prognostic tumor-infiltrating immune cells of endometrial adenocarcinoma.The gene expression profiles of endometrial adenocarcinoma were downloaded from the Cancer Genome Atlas (TCGA). The abundance of tumor-infiltrating immune cells in endometrial adenocarcinoma samples was calculated by CIBERSORT algorithm. Kaplan-Meier analysis was used to identify prognostic tumor-infiltrating immune cells.This study identified 22 kinds of tumor-infiltrating immune cells. Macrophages M0 and CD8âT cells were prognostic factors of endometrial adenocarcinoma. The abundance of macrophages M0 (Pâ=â.038) was significantly correlated with better prognosis of endometrial adenocarcinoma. In contrast, the abundance of CD8âT cells (Pâ=â.049) was associated with poor prognosis of endometrial adenocarcinoma.Tumor-infiltrati macrophages M0 and CD8âT cells were prognostic factors of endometrial adenocarcinoma.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Adenocarcinoma
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Linfócitos do Interstício Tumoral
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Neoplasias do Endométrio
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Linfócitos T CD8-Positivos
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Macrófagos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2021
Tipo de documento:
Article