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Highly efficient CD4+ T cell targeting and genetic recombination using engineered CD4+ cell-homing mRNA-LNPs.
Tombácz, István; Laczkó, Dorottya; Shahnawaz, Hamna; Muramatsu, Hiromi; Natesan, Ambika; Yadegari, Amir; Papp, Tyler E; Alameh, Mohamad-Gabriel; Shuvaev, Vladimir; Mui, Barbara L; Tam, Ying K; Muzykantov, Vladimir; Pardi, Norbert; Weissman, Drew; Parhiz, Hamideh.
Afiliação
  • Tombácz I; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Laczkó D; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Shahnawaz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Muramatsu H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Natesan A; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Yadegari A; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Papp TE; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Alameh MG; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Shuvaev V; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Mui BL; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Tam YK; Acuitas Therapeutics, Vancouver, BC V6T 1Z3, Canada.
  • Muzykantov V; Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Pardi N; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Weissman D; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dreww@pennmedicine.upenn.edu.
  • Parhiz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: Hamideh.Parhiz@pennmedicine.upenn.edu.
Mol Ther ; 29(11): 3293-3304, 2021 11 03.
Article em En | MEDLINE | ID: mdl-34091054

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Recombinação Genética / RNA Mensageiro / Linfócitos T CD4-Positivos / Nanopartículas / Lipídeos Limite: Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Recombinação Genética / RNA Mensageiro / Linfócitos T CD4-Positivos / Nanopartículas / Lipídeos Limite: Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos