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Short Communication: Persistence of HIV After Allogeneic Bone Marrow Transplant in a Dually Infected Individual.
Capoferri, Adam A; Redd, Andrew D; Gocke, Christopher D; Clark, Laura R; Ambinder, Richard F; Durand, Christine M.
Afiliação
  • Capoferri AA; School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Redd AD; School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Gocke CD; Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA.
  • Clark LR; Sidney Kimmel Cancer Center, Baltimore, Maryland, USA.
  • Ambinder RF; School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Durand CM; Sidney Kimmel Cancer Center, Baltimore, Maryland, USA.
AIDS Res Hum Retroviruses ; 38(1): 33-36, 2022 01.
Article em En | MEDLINE | ID: mdl-34107771
Allogeneic bone marrow transplant (alloBMT) with continuous antiretroviral therapy alone has not been shown to completely eradicate HIV, possibly due to HIV persistence in rare residual host cells or infection of donor cells. Within a trial of alloBMT in individuals with hematological malignancies and HIV (ClinicalTrials.gov, NCT01836068), we measured HIV reservoirs longitudinally using a quantitative viral outgrowth assay. We sequenced the reverse transcriptase region of pol for replication-competent virus and performed maximum-likelihood phylogenetic reconstruction. Replacement of host cells was measured using short-tandem repeats. In one participant who had ≥99.5% donor cell replacement, HIV reservoirs declined from 2.2 infectious units per million to undetectable levels at post-alloBMT time points except for week 64. Sequence analysis revealed dual infection pre-alloBMT. Replication-competent virus isolated at week 64 post-alloBMT was identical to a pre-alloBMT variant. This report provides proof-of-concept that minor replication-competent HIV variants can persist at low levels despite ≥99.5% donor cell engraftment post-alloBMT.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Transplante_de_medula_ossea Base de dados: MEDLINE Assunto principal: Infecções por HIV / Transplante de Células-Tronco Hematopoéticas Limite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Transplante_de_medula_ossea Base de dados: MEDLINE Assunto principal: Infecções por HIV / Transplante de Células-Tronco Hematopoéticas Limite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Assunto da revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos