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Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Banerjee, Abhisek; Velagaleti, Ranganadh; Patil, Sandip; Pawar, Mahesh; Yadav, Pravin; Kadam, Pradip; Qadri, Mohammad Mohsin; Chakraborti, Samitabh; Saini, Jagmohan S; Behera, Dayanidhi B; Karanjai, Keya; Iyer, Pravin S; Gharat, Laxmikant A; Das, Sanjib.
Afiliação
  • Banerjee A; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Velagaleti R; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Patil S; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Pawar M; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Yadav P; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Kadam P; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Qadri MM; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Chakraborti S; Pharmacology Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Saini JS; Computational Chemistry, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Behera DB; Drug Metabolism and Pharmacokinetics, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Karanjai K; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Iyer PS; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.; Pharmacology Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.; Computational Chemistry, Glenmark Research Centre, A-60
  • Gharat LA; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.
  • Das S; Medicinal Chemistry Division, Glenmark Research Centre, A-607, TTC Industrial Area, MIDC Mahape, Navi Mumbai 400 709, India.. Electronic address: Sanjib.Das@glenmarkpharma.com.
Bioorg Med Chem Lett ; 47: 128202, 2021 09 01.
Article em En | MEDLINE | ID: mdl-34139325
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Aorta / Síndrome do Desconforto Respiratório / Inibidores de Cisteína Proteinase / Catepsina C / Tratamento Farmacológico da COVID-19 Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Aorta / Síndrome do Desconforto Respiratório / Inibidores de Cisteína Proteinase / Catepsina C / Tratamento Farmacológico da COVID-19 Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia