Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1.

Hu, Shuiqing; Luo, Jinlan; Fu, Menglu; Luo, Liman; Cai, Yueting; Li, Wenhua; Li, Yuanyuan; Dong, Ruolan; Yang, Yan; Tu, Ling; Xu, Xizhen

Hu, Shuiqing; Luo, Jinlan; Fu, Menglu; Luo, Liman; Cai, Yueting; Li, Wenhua; Li, Yuanyuan; Dong, Ruolan; Yang, Yan; Tu, Ling; Xu, Xizhen.

Afiliação

Hu S; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Luo J; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, People's Republic of China.
Fu M; Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Luo L; Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Cai Y; Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Li W; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Li Y; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, People's Republic of China.
Dong R; Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Yang Y; Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Tu L; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xu X; Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Am J Physiol Heart Circ Physiol ; 321(2): H353-H368, 2021 08 01.

Article em En | MEDLINE | ID: mdl-34142887

Assuntos

Aorta/efeitos dos fármacos; Epóxido Hidrolases/genética; Niacinamida/farmacologia; Nicotina/farmacologia; Agonistas Nicotínicos/farmacologia; Sirtuína 1/metabolismo; Rigidez Vascular/efeitos dos fármacos; Complexo Vitamínico B/farmacologia; Ácido 8,11,14-Eicosatrienoico/análogos & derivados; Ácido 8,11,14-Eicosatrienoico/farmacologia; Proteínas Adaptadoras de Transdução de Sinal/efeitos dos fármacos; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Animais; Aorta/metabolismo; Aorta/fisiopatologia; Metaloproteinase 2 da Matriz/efeitos dos fármacos; Metaloproteinase 2 da Matriz/genética; Camundongos; Camundongos Knockout; Sirtuína 1/antagonistas & inibidores; Sirtuína 1/efeitos dos fármacos; Rigidez Vascular/genética; Vasodilatadores/farmacologia; Proteínas de Sinalização YAP

Palavras-chave

SIRT1; arterial stiffness; nicotine; soluble epoxide hydrolase; vascular remodeling

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Aorta / Complexo Vitamínico B / Niacinamida / Agonistas Nicotínicos / Epóxido Hidrolases / Sirtuína 1 / Rigidez Vascular / Nicotina Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Am J Physiol Heart Circ Physiol Assunto da revista: CARDIOLOGIA / FISIOLOGIA Ano de publicação: 2021 Tipo de documento: Article

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