The importance of viral and cellular factors on flavivirus entry.
Curr Opin Virol
; 49: 164-175, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34171540
ABSTRACT
The flavivirus are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than 70 viruses, and despite genomic and structural similarities, infections by different flaviviruses result in different clinical presentations. In the absence of a safe and effective vaccine against these infections, the search for new strategies to inhibit viral infection is necessary. The life cycle of arboviruses begins with the entry process composed of multiple steps:
attachment, internalization, endosomal escape and capsid uncoating. This mini-review describes factors and mechanisms involved in the viral entry as events required to take over the cellular machinery and host factors and cellular pathways commonly used by flaviviruses as possible approaches for developing broad-spectrum antiviral drugs.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Infecções por Flavivirus
/
Internalização do Vírus
/
Flavivirus
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Virol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
México