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A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
Zhou, Jia; Gelot, Camille; Pantelidou, Constantia; Li, Adam; Yücel, Hatice; Davis, Rachel E; Färkkilä, Anniina; Kochupurakkal, Bose; Syed, Aleem; Shapiro, Geoffrey I; Tainer, John A; Blagg, Brian S J; Ceccaldi, Raphael; D'Andrea, Alan D.
Afiliação
  • Zhou J; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Gelot C; Inserm U830, PSL Research University, Institut Curie, Paris, France.
  • Pantelidou C; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Li A; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Yücel H; Inserm U830, PSL Research University, Institut Curie, Paris, France.
  • Davis RE; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
  • Färkkilä A; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Kochupurakkal B; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Syed A; Departments of Cancer Biology and Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Tainer JA; Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Blagg BSJ; Departments of Cancer Biology and Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ceccaldi R; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.
  • D'Andrea AD; Inserm U830, PSL Research University, Institut Curie, Paris, France. raphael.ceccaldi@curie.fr.
Nat Cancer ; 2(6): 598-610, 2021 06.
Article em En | MEDLINE | ID: mdl-34179826
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Recombinação Homóloga Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Nat Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Recombinação Homóloga Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Nat Cancer Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos