A Mesoscale Computational Model for Microvascular Oxygen Transfer.
Ann Biomed Eng
; 49(12): 3356-3373, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34184146
ABSTRACT
We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heterogeneity of oxygenation in the tissue microenvironment. Finally, we discuss the importance of these effects in the treatment of cancer using radiotherapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Velocidade do Fluxo Sanguíneo
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Microcirculação
/
Modelos Cardiovasculares
Limite:
Humans
Idioma:
En
Revista:
Ann Biomed Eng
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália