Iguratimod decreases bleomycin-induced pulmonary fibrosis in association with inhibition of TNF-&#945; in mice.

Shao, Siqi; Qu, Ziye; Liang, Yiwen; Xu, Yan; Zhou, Dongmei; Li, Danhua; Zhang, Ying; Yin, Songlou

Iguratimod decreases bleomycin-induced pulmonary fibrosis in association with inhibition of TNF-α in mice.

Shao, Siqi; Qu, Ziye; Liang, Yiwen; Xu, Yan; Zhou, Dongmei; Li, Danhua; Zhang, Ying; Yin, Songlou.

Afiliação

Shao S; Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; The First Clinical Medicine School, Xuzhou Medical University, Xuzhou 221002, China.
Qu Z; Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; The First Clinical Medicine School, Xuzhou Medical University, Xuzhou 221002, China.
Liang Y; Blood Diseases Institute, Xuzhou Medical University, Xuzhou 221002, China.
Xu Y; Blood Diseases Institute, Xuzhou Medical University, Xuzhou 221002, China.
Zhou D; Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; The First Clinical Medicine School, Xuzhou Medical University, Xuzhou 221002, China.
Li D; Department of Pathology, Laboratory of Clinical and Experimental Pathology, Xuzhou Medical University, Xuzhou 221004, China.
Zhang Y; Department of Pathology, Laboratory of Clinical and Experimental Pathology, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: zy807411916@163.com.
Yin S; Department of Rheumatology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; The First Clinical Medicine School, Xuzhou Medical University, Xuzhou 221002, China. Electronic address: yinsonglou@163.com.

Int Immunopharmacol ; 99: 107936, 2021 Oct.

Article em En | MEDLINE | ID: mdl-34284287

Assuntos

Bleomicina/metabolismo; Cromonas/metabolismo; Fibrose Pulmonar/metabolismo; Sulfonamidas/metabolismo; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Células A549; Actinas/metabolismo; Animais; Caderinas/genética; Caderinas/metabolismo; Colágeno/metabolismo; Modelos Animais de Doenças; Transição Epitelial-Mesenquimal; Humanos; Metaloproteinase 2 da Matriz; Camundongos; NF-kappa B/metabolismo; Pneumonia/metabolismo; Transdução de Sinais; Fator de Transcrição RelA/metabolismo; Vimentina/genética; Vimentina/metabolismo

Palavras-chave

Iguratimod; Pulmonary fibrosis; Tumor necrosis factor-α

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Sulfonamidas / Bleomicina / Cromonas / Fator de Necrose Tumoral alfa Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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