Progression of melanoma is suppressed by targeting all transforming growth factor­ß isoforms with an Fc chimeric receptor.

Kodama, Shingo; Podyma-Inoue, Katarzyna &#913;; Uchihashi, Toshihiro; Kurioka, Kyoko; Takahashi, Hitomi; Sugauchi, Akinari; Takahashi, Kazuki; Inubushi, Toshihiro; Kogo, Mikihiko; Tanaka, Susumu; Watabe, Tetsuro

Progression of melanoma is suppressed by targeting all transforming growth factorß isoforms with an Fc chimeric receptor.

Kodama, Shingo; Podyma-Inoue, Katarzyna Α; Uchihashi, Toshihiro; Kurioka, Kyoko; Takahashi, Hitomi; Sugauchi, Akinari; Takahashi, Kazuki; Inubushi, Toshihiro; Kogo, Mikihiko; Tanaka, Susumu; Watabe, Tetsuro.

Afiliação

Kodama S; The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Podyma-Inoue KΑ; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 1138549, Japan.
Uchihashi T; The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Kurioka K; The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Takahashi H; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 1138549, Japan.
Sugauchi A; The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Takahashi K; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 1138549, Japan.
Inubushi T; Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Kogo M; The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Tanaka S; The First Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka 5650871, Japan.
Watabe T; Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo, Tokyo 1138549, Japan.

Oncol Rep ; 46(3)2021 Sep.

Article em En | MEDLINE | ID: mdl-34296292

Assuntos

Melanoma/metabolismo; Receptores Fc/metabolismo; Neoplasias Cutâneas/metabolismo; Fator de Crescimento Transformador beta1/biossíntese; Animais; Proliferação de Células; Citocinas/metabolismo; Progressão da Doença; Transição Epitelial-Mesenquimal; Células HEK293; Humanos; Imunoglobulina G/química; Melanoma/patologia; Melanoma Experimental; Camundongos; Ligação Proteica; Isoformas de Proteínas; Receptores de Antígenos Quiméricos/química; Transdução de Sinais; Neoplasias Cutâneas/patologia; Proteínas Smad/metabolismo; Microambiente Tumoral

Palavras-chave

EMT; Fc chimeric receptor; TGFß; melanoma; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pele Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Receptores Fc / Fator de Crescimento Transformador beta1 / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncol Rep Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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