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Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs.
Ciftci, Halil I; Bayrak, Nilüfer; Yildiz, Mahmut; Yildirim, Hatice; Sever, Belgin; Tateishi, Hiroshi; Otsuka, Masami; Fujita, Mikako; Tuyun, Amaç Fatih.
Afiliação
  • Ciftci HI; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan.
  • Bayrak N; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey.
  • Yildiz M; Chemistry Department, Gebze Technical University, Gebze, Kocaeli, Turkey.
  • Yildirim H; Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Avcilar, Istanbul, Turkey.
  • Sever B; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
  • Tateishi H; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan.
  • Otsuka M; Department of Drug Discovery, Science Farm Ltd., Kumamoto, Japan; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan.
  • Fujita M; Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, School of Pharmacy, Kumamoto University, Kumamoto, Japan. Electronic address: mfujita@kumammot-u.ac.jp.
  • Tuyun AF; Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey. Electronic address: aftuyun@istanbul.edu.tr.
Bioorg Chem ; 114: 105160, 2021 09.
Article em En | MEDLINE | ID: mdl-34328861
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Proteínas Proto-Oncogênicas c-abl / Inibidores de Proteínas Quinases / Aminoquinolinas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Proteínas Proto-Oncogênicas c-abl / Inibidores de Proteínas Quinases / Aminoquinolinas / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão