Long-term outcome in patients with takotsubo syndrome : A single center study from Vienna.
Wien Klin Wochenschr
; 134(7-8): 261-268, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-34415428
BACKGROUND: There is an increasing amount of evidence suggesting multiple fatal complications in takotsubo syndrome; however, findings on the long-term outcome are scarce and show inconsistent evidence. METHODS: This is a single center study of long-term prognosis in takotsubo patients admitted to the Klinik Ottakring, Vienna, Austria, from September 2006 to August 2019. We investigated the clinical features, prognostic factors and outcome of patients with takotsubo syndrome. Furthermore, survivors and non-survivors and patients with a different cause of death were compared. RESULTS: Overall, 147 patients were included in the study and 49 takotsubo patients (33.3%) died during the follow-up, with a median of 126 months. The most common cause of death was a non-cardiac cause (71.4% of all deaths), especially malignancies (26.5% of all deaths). Moreover, non-survivors were older and more often men with more comorbidities (chronic kidney disease, malignancy). Patients who died because of cardiovascular disease were older and more often women than patients who died due to non-cardiovascular cause. Adjusted analysis showed no feature of an independent predictor of cardiovascular mortality for takotsubo patients. Female gender (HRâ¯= 0.32, CI: 0.16-0.64, pâ¯< 0.001), cancer (HRâ¯= 2.35, CI: 1.15-4.8, pâ¯= 0.019) and chronic kidney disease (HRâ¯= 2.61, CI: 1.11-6.14, pâ¯= 0.028) showed to be independent predictors of non-cardiovascular mortality. CONCLUSION: Long-term prognosis of takotsubo patients is not favorable, mainly due to noncardiac comorbidities. Hence, consequent outpatient care in regular intervals after a takotsubo event based on risk factor control and early detection of malignancies seems justified.
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Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
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Cardiomiopatia de Takotsubo
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Neoplasias
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Wien Klin Wochenschr
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Áustria